发明名称 |
Bispecific binding molecules for anti-angiogenesis therapy |
摘要 |
<p>Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.</p> |
申请公布号 |
AU2010302589(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
AU20100302589 |
申请日期 |
2010.10.01 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
BORGES, ERIC;GSCHWIND, ANDREAS;BOUCNEAU, JOACHIM;DE TAVERNIER, EVELYN;KOLKMAN, JOOST;MERCHIERS, PASCAL;VAN HOORICK, DIANE |
分类号 |
C07K16/28;A61P35/00;C07K16/18;C07K16/22 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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