发明名称 |
COMPOSITIONS AND METHODS FOR TREATING ENDOCRINE, GASTROINTESTINAL OR AUTOIMMUNE DISORDERS |
摘要 |
Recombinant cells and methods are provided that relate to the use of isolated, engineered recombinant cells to directly or indirectly treat diseases or disorders in a mammalian host such as endocrine, gastrointestinal or autoimmune disorders. A recombinant cell is provided that comprises a signal sequence and a promoter, wherein: the signal sequence is capable of regulating signal-dependent expression of a target nucleic acid in a host or is capable of regulating signal-dependent expression of a target nucleic acid in response to an environmental stimulus, the cell is derived from an enteric or a commensal bacterium, and the target nucleic acid encodes a mammalian factor that promotes normal functioning of a physiological process in the host or is effective in preventing onset, establishment, or spread of a non-infectious disease in the host. The recombinant cell is administered to the host to treat the disease or disorder. |
申请公布号 |
WO2012051431(A2) |
申请公布日期 |
2012.04.19 |
申请号 |
WO2011US56174 |
申请日期 |
2011.10.13 |
申请人 |
CORNELL UNIVERSITY;MARCH, JOHN C.;DUAN, FAPING |
发明人 |
MARCH, JOHN C.;DUAN, FAPING |
分类号 |
C12N15/74;A61K35/74;A61K48/00;A61P3/10;C12N1/21;C12N15/12;C12N15/70 |
主分类号 |
C12N15/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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