CELL-PERMEABLE RECOMBINANT PARKIN PROTEIN AND A PHARMACEUTICAL COMPOSITION FOR TREATING DEGENERATIVE BRAIN DISEASES CONTAINING THE SAME

摘要

The present invention relates to: a recombinant parkin protein having cell-permeable properties, wherein a macromolecule transduction domain (MTD) is fused to a degenerative-brain-disease therapeutic protein parkin; and a pharmaceutical composition or the like for treating degenerative brain diseases which contains the cell-permeable recombinant parkin protein as an active ingredient. For the recombinant parkin protein having cell-permeable properties of the present invention, a cell-permeable recombinant protein is produced in which a macromolecule transduction domain is fused to a parkin protein which is a dopamine neuron death suppression factor, and, because the same is endowed with the ability to be transmitted into cells, in use the protein is transmitted into dopamine neurons in in vitro or in vivo environments such that cell death is suppressed, or else there is a dopamine-secretion increasing effect whereby the protein can be used in studies which aim to treat Parkinson's disease, and the protein can be used to advantage as a therapeutic agent for human degenerative brain diseases.