发明名称 |
Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors |
摘要 |
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect discloses hetero pyrrole analogs acting as antagonists for the CB1 and/or the CB2 receptors. Another aspect discloses hetero pyrrole analogs having selectivity for the CB1 or CB2 cannabinoid receptor. Also disclosed are pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect. |
申请公布号 |
US2012095047(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201113334163 |
申请日期 |
2011.12.22 |
申请人 |
MAKRIYANNIS ALEXANDROS;THOTAPALLY RAJESH;VEMURI VENKATA KIRAN RAO;OLSZEWSKA TERESA;UNIVERSITY OF CONNECTICUT |
发明人 |
MAKRIYANNIS ALEXANDROS;THOTAPALLY RAJESH;VEMURI VENKATA KIRAN RAO;OLSZEWSKA TERESA |
分类号 |
A61K31/4545;A61K31/4164;A61K31/4178;A61K31/454;A61P1/08;A61P3/04;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P25/34;A61P25/36;A61P29/00;A61P35/00;A61P43/00;C07D233/88;C07D233/90;C07D401/12;C07D401/14;C07D403/10;C07D417/14 |
主分类号 |
A61K31/4545 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|