A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE, A CORTICOSTEROID, AND AN ANTIFUNGAL AGENT, AND INCORPORATING A BIOPOLYMER, AND A PROCESS TO MAKE IT

摘要

The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises: a) a biopolymer in the form of Chitosan, b) active pharmaceutical ingredients (APIs), in the form of fusidic acid that has been generated in situ from sodium fusidate, Hydrocortisone acetate & Miconazole nitrate, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants, and d) water. The invention also discloses a process to make medicinal cream containing Fusidic acid formed in situ from Sodium Fusidate by converting it into Fusidic acid under oxygen-free environment created using inert gas. The cream has greater shelf-life and the finer particle size of the API than the conventional creams containing Fusidic acid.