发明名称 |
METHOD FOR PURIFICATION OF COMPLEMENT FACTOR H |
摘要 |
<p>A method for purification of complement Factor H from a complement Factor H containing source such as blood or blood plasma, in particular a caprylate precipitate of a Factor H containing source, which is e.g. obtained by addition of caprylate ions to fractions of blood or plasma, comprising the steps of: a)providing a Factor H containing source, in particular reconstitution of caprylate precipitate to provide a complement Factor H containing solution; b)performing a cation exchange chromatography in particular as first chromatographic step; c)performing an anion exchange chromatography; d)performing a hydroxyl apatite chromatography; e)followed by ultra/diafiltration to obtain a complement Factor H concentrate.</p> |
申请公布号 |
CA2812643(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
CA20112812643 |
申请日期 |
2011.10.13 |
申请人 |
OCTAPHARMA AG |
发明人 |
BRANDSTAETTER, HUBERT;SCHULZ, PETRA;ROEMISCH, JUERGEN |
分类号 |
A61K38/17;C07K1/18;C07K14/435 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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