发明名称 |
BOOSTING HUMAN DENDRITIC CELL DEVELOPMENT, HOMEOSTASIS AND FUNCTION IN XENOGRAFTED IMMUNODEFICIENT MICE |
摘要 |
The present invention relates to a transgenic animal mode system based on the development of transgenic mice bearing components of the human immune system. Specifically, the Invention relates to a Flk2 deficient Rag “γc” transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention further presides methods for increasing the numbers of functionally competent human dendritic cells is and the hematopoietic targets cells that they interact with in said transgenic mouse through the administration of Flk2L. The transgenic animal model system of the invention may be used for testing human vaccine candidates, for screening potential Immune adjuvants and for developing novel therapeutics. |
申请公布号 |
US2012094312(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201013262567 |
申请日期 |
2010.04.02 |
申请人 |
DI SANTO JAMES;MENTION JEAN-JACQUES;INSTITUT PASTEUR;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC HERCHE) |
发明人 |
DI SANTO JAMES;MENTION JEAN-JACQUES |
分类号 |
A01K67/027;G01N33/53 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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