发明名称 |
LH-TYPE BISPECIFIC ANTIBODY |
摘要 |
Provided are a novel diabody type bispecific antibody, the function of which as a bispecific antibody is improved to provide a higher additional value, such as cost saving caused by a reduction in dose, to a drug; and a method for producing the same. A humanized diabody type bispecific antibody (LH-diabody type bispecific antibody) characterized in that an L-chain is located in the N-terminal side in each polypeptide (LH type); a humanized high-functional bispecific antibody which contains said LH diabody type bispecific antibody; a nucleic acid molecule encoding both of two kinds of single-stranded polypeptides constituting said bispecific antibody; and a method for producing said antibody which comprises culturing a host cell having been transformed by an expression vector containing said nucleic acid molecule.
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申请公布号 |
US2012095191(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201013257614 |
申请日期 |
2010.01.04 |
申请人 |
KUMAGAI IZUMI;ASANO RYUTARO;UMETSU MITSUO;TOHOKU UNIVERSITY |
发明人 |
KUMAGAI IZUMI;ASANO RYUTARO;UMETSU MITSUO |
分类号 |
C07K16/46;C12N1/21;C12N15/62;C12N15/63;C12P21/02 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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