摘要 |
The purpose of the present invention is to provide a pharmaceutical composition which comprises a medicinal agent and a collagen and has good handleability and sustained release properties. The purpose is achieved by a sustained-release pharmaceutical composition comprising a medicinal agent, a collagen and at least one saccharide selected from monosaccharides, disaccharides, trisaccharides and tetrasaccharides. The present inventors have found that a collagen containing a saccharide is gelated when the collagen is administered to a living body. Based on this finding, it is also found that the release rate of a medicinal agent can be controlled when the medicinal agent is prepared into a composition comprising the medicinal agent, a collagen and a saccharide, and that the composition can be used as a sustained-release pharmaceutical composition. |
申请人 |
KYOTO UNIVERSITY;KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION;KAKEN PHARMACEUTICAL CO., LTD.;KOKEN CO., LTD.;FUKUSHIMA, MASANORI;MASTUBARA, HIROAKI;MATOBA, SATOAKI;HIJIKATA, SHIGEKI;ASO, YU;SATO, TSUTOMU |
发明人 |
FUKUSHIMA, MASANORI;MASTUBARA, HIROAKI;MATOBA, SATOAKI;HIJIKATA, SHIGEKI;ASO, YU;SATO, TSUTOMU |