Propane-I-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof

摘要

The present invention is related to an improved method for the manufacture of Micro- precipitated Bulk Powder (MBP) containing the active pharmaceutical ingredient Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS). The invention is further directed to pharmaceutical compositions containing said MBP, as well as its use in the manufacture of medicaments for the treatment of cancer. Formula (I).