发明名称 |
COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ORGAN INJURY AND/OR DYSFUNCTION |
摘要 |
The present embodiments relate to compositions and methods for treating the inflammatory response in a tissue or organ, such as the liver, by contacting the tissue with a tissue-specific gap junction inhibitor; and compositions and methods of reducing the toxicity of an agent by administering a gap junction inhibitor either simultaneously or sequentially with exposure to the agent. For example, inhibition of the liver-specific gap junction connexin 32 by 2 aminoethyoxydiphenyl-borate, effectively treats and/or prevents hepatotoxicity. |
申请公布号 |
WO2011163308(A3) |
申请公布日期 |
2012.04.19 |
申请号 |
WO2011US41363 |
申请日期 |
2011.06.22 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;PATEL, SURAJ J.;MILWID, JACK M.;YARMUSH, MARTIN L.;KING, KEVIN R. |
发明人 |
PATEL, SURAJ J.;MILWID, JACK M.;YARMUSH, MARTIN L.;KING, KEVIN R. |
分类号 |
A61K39/395;A61K31/7088;A61K31/7105;A61K38/16;A61P29/00;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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