发明名称 |
SCREENING ASSAYS FOR AGENTS THAT ALTER INHIBITOR OF APOPTOSIS (IAP) PROTEIN REGULATION OF CASPASE ACTIVITY |
摘要 |
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7 or a pro-caspase such as pro-caspase-9, or that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. |
申请公布号 |
US2012094922(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201113287979 |
申请日期 |
2011.11.02 |
申请人 |
REED JOHN C.;DEVERAUX QUINN;SALVESEN GUY S.;TAKAHASHI RYOSUKE;ROY NATALIE;SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE |
发明人 |
REED JOHN C.;DEVERAUX QUINN;SALVESEN GUY S.;TAKAHASHI RYOSUKE;ROY NATALIE |
分类号 |
A61K38/02;A61P25/28;A61P35/00;C12Q1/37;G01N33/573 |
主分类号 |
A61K38/02 |
代理机构 |
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地址 |
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