METHODS FOR IDENTIFYING MODULATORS OF TRIGLYCERIDE METABOLISM, FOR MODULATING TRIGLYCERIDE METABOLISM AND FOR IDENTIFYING SUBJECTS AT RISK FOR ABNORMAL TRIGLYCERIDE METABOLISM

摘要

The present invention is based, at least in part, on the discovery that the transcription factor CREB-H modulates lipid metabolism. Mice bearing a null mutation in CREB-H exhibit a hypertriglyceridemia secondary to inefficient triglyceride clearance. Mutations in CREB3L3 have also been identified which are predictive of the propensity to develop abnormal triglyceride metabolism. Accordingly, methods for identifying agents that increase CREB-H expression and/or activity, methods for increasing CREB-H protein levels in cells, and methods for identifying subjects at risk for abnormal triglyceride metabolism are provided.