发明名称 |
ATTENUATED ENTEROHEMORRHAGIC E.COLI-BASED VACCINE VECTOR AND METHODS RELATING THERETO |
摘要 |
An attenuated enterohemorrhagic E. coli-based vaccine vector is disclosed. Enterotoxigenic E. coli colonization factor antigen 1 and the B subunit of E. coli heat labile toxin have been expressed in the attenuated enterohemorrhagic E. coli vector strain. Immunized animals are further protected against lethal and non lethal challenges with the enterotoxigenic E. coli strain. Immunization of mice with the vaccine construct induces mucosal antibody against both antigens, establishing the attenuated E. coli vector strain as a generally useful vector for presenting one or more antigens to a subject in a vaccine.
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申请公布号 |
US2012093870(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201013378116 |
申请日期 |
2010.06.30 |
申请人 |
STC.UNM |
发明人 |
BOEDEKER EDGAR C.;BYRD ISAAC WYATT |
分类号 |
A61K39/108;A61P31/04;A61P37/04 |
主分类号 |
A61K39/108 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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