发明名称 |
PEPTIDES AND USES |
摘要 |
Disclosed herein are zinc finger peptides having at least 4 zinc finger domains, such as 6, 11, 12 or 18 zinc finger domains. The zinc finger peptides may be fused to effector domains for modulating gene expression. Zinc finger peptides of the invention are useful for targeting trinucleotide-repeat sequences in mutant genes and may have applications in gene therapy. The zinc finger peptides may have nucleic acid recognition sequences according to SEQ ID NO: 101. Also disclosed are methods for constructing poly-zinc finger peptides having arrays of at least 8 zinc finger domains, along with zinc finger frameworks that may be useful for selecting zinc finger peptides from libraries. |
申请公布号 |
WO2012049332(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
WO2011EP68139 |
申请日期 |
2011.10.17 |
申请人 |
FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA;ISALAN, MARK;GARRIGA-CANUT, MIREIA |
发明人 |
ISALAN, MARK;GARRIGA-CANUT, MIREIA |
分类号 |
C07K14/47;A61K38/48;A61P25/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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