发明名称 |
PROTEASE FOR WOUND CONDITIONING AND SKIN CARE |
摘要 |
We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or consisting of the amino acid sequence of SEQ ID NO: 4 as well as to nucleic acid molecules encoding precursors or fragments of said serine protease; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 3; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80% identical to the amino acid sequence of (a), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 80% identical to the nucleotide sequence of (b), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U. |
申请公布号 |
US2012093788(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201013254157 |
申请日期 |
2010.03.03 |
申请人 |
NIEHAUS FRANK;ECK JUERGEN;SCHULZE RENATE;KROHN MICHAEL;B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATIONNETWORK AG |
发明人 |
NIEHAUS FRANK;ECK JUERGEN;SCHULZE RENATE;KROHN MICHAEL |
分类号 |
A61K48/00;A61K31/7088;A61K35/74;A61K36/06;A61K36/064;A61K38/48;A61P17/00;A61P17/02;C07H21/04;C07K16/40;C12N1/19;C12N1/21;C12N9/50;C12N15/63 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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