发明名称 |
ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY. |
摘要 |
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided. |
申请公布号 |
MX2011011728(A) |
申请公布日期 |
2012.04.19 |
申请号 |
MX20110011728 |
申请日期 |
2010.05.04 |
申请人 |
ABBOTT RESEARCH B.V. |
发明人 |
WEI LIU;JOHN POWELL;MARK MAGINN;DUNCAN CASSON;SANDEEP DUTTA;JERRY A. HALL;ANDREA BEST |
分类号 |
C07K16/22;A61K39/395;A61P25/00;C12N5/10;C12N15/13 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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