| 摘要 |
The present invention in one embodiment uses detection of isoforms of CAP37 in a fluid as an early detection marker for a chronic inflammatory- associated disease. Chronic inflammatory-related diseases may include, for example, atherosclerosis, psoriasis, osteoarthritis, and Alzheimer's disease. The invention is also directed to isoforms of CAP37 protein having apparent molecular weights of about 135 kDa (± 15 kDa) and about 100 kDa (± 15 kDa) as assessed by SDS PAGE under reducing conditions, and their use as biomarkers for the presence of a chronic inflammatory-associated disease in a subject. The invention is also directed to monoclonal and/or polyclonal antibodies raised against such isoforms of CAP37 protein and kits and diagnostic tests comprising these antibodies. |
