Observations regarding the role of MUC1 in promoting the nuclear accumulation of EGFR led us to propose the development of peptides to block nuclear accumulation of EGFR as a means to block breast cancer progression. One exemplary peptide, the ENLS1 peptide, promotes cell death in breast cancer cell lines. Studies in the MMTV-pyMT mouse model of breast cancer demonstrate significant anti-tumor activity.
申请公布号
WO2012051247(A2)
申请公布日期
2012.04.19
申请号
WO2011US55894
申请日期
2011.10.12
申请人
ARIZONA BIOMEDICAL RESEARCH COMMISSION;SCHROEDER, JOYCE, A.;BITLER, BENJAMIN, G.;GOVERDHAN, AARTHI