发明名称 |
Agents for Treatment of HCV and Methods of Use |
摘要 |
An amphipathic helix at the approximate N-terminus of Hepatitis C virus (HCV) nonstructural proteins mediates the association of these proteins with cytoplasmic membranes in infected cells. This association is essential for replication. Thus, assessing the ability of compounds or protocols to disrupt the association of such helices with cytoplasmic membranes permits identification of compounds and protocols which are useful in the treatment of HCV infection. Also useful in the invention are mimics, or function-disrupting ligands, of an amphipathic helix of the nonstructural proteins described herein and antibodies and fragments thereof immunoreactive with said helix.
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申请公布号 |
US2012093849(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201113326793 |
申请日期 |
2011.12.15 |
申请人 |
GLENN JEFFREY S.;MYERS TINA MARIE;GLASS JOHN IRVIN |
发明人 |
GLENN JEFFREY S.;MYERS TINA MARIE;GLASS JOHN IRVIN |
分类号 |
A61K39/29;A61K38/00;A61K38/16;A61K39/00;A61P31/14;C07H21/02;C07K14/16;C07K14/18;C12Q1/70;G01N33/576 |
主分类号 |
A61K39/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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