发明名称 |
STABLE CYCLOSPORINE CONTAINING OPHTHALMIC EMULSION FOR TREATING DRY EYES |
摘要 |
Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 μm including at least one plant-derived oil other than castor oil wherein the oil comprises only aliphatic side chains free of polar pendent groups. The oil-in-water emulsion ophthalmic topical liquid compositions also include a hydrophilic surfactant having an HLB value between approximately 10 and 14, a vegetable oil-derived hydrophobic non-co-block surfactant having unsaturated side chains that contain less than four oxygen atoms having an HLB value between approximately 4 and 6 and is a liquid at room temperature. The oil-in-water emulsion ophthalmic topical liquid compositions disclosed herein can further include an amount of cyclosporine A or polyphenol in an amount effective to relieve dry eye symptoms. |
申请公布号 |
US2012093894(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201013375847 |
申请日期 |
2010.06.02 |
申请人 |
YU ZHI-JIAN;HUTH STANLEY W.;DEMICHELE STEPHEN J.;ABBOTT MEDICAL OPTICS INC. |
发明人 |
YU ZHI-JIAN;HUTH STANLEY W.;DEMICHELE STEPHEN J. |
分类号 |
A61K38/13;A61K9/107;A61K31/12;A61K31/353;A61K36/82;A61P27/02 |
主分类号 |
A61K38/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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