发明名称 |
Method of Modification of Hyaluronic Acid by Means of (O-ACYL-O'-ALKYL Carbonate-Substituted Pyridine) Complex |
摘要 |
This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R—CO—O—CO—O—R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO—O—CO—O—R1)n, crosslinked hyaluronic acid derivatives are formed. |
申请公布号 |
US2012095205(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201013256966 |
申请日期 |
2010.03.13 |
申请人 |
BUFFA RADOVAN;VELEBNY VLADIMIR;POSPISILOVA LUCIE;PRIKOPOVA EVA;PRAVDA MARTIN;NIKODYM PAVEL;PALEK LUKAS;CONTIPRO C |
发明人 |
BUFFA RADOVAN;VELEBNY VLADIMIR;POSPISILOVA LUCIE;PRIKOPOVA EVA;PRAVDA MARTIN;NIKODYM PAVEL;PALEK LUKAS |
分类号 |
C08B37/00 |
主分类号 |
C08B37/00 |
代理机构 |
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代理人 |
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地址 |
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