发明名称 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
摘要 This invention provides a compound having the structure wherein α, &bgr;, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF&kgr;-B activation in a population of cells.
申请公布号 US2012095051(A1) 申请公布日期 2012.04.19
申请号 US201013319478 申请日期 2010.05.14
申请人 JOHNSON FRANCIS;GOLUB LORNE 发明人 JOHNSON FRANCIS;GOLUB LORNE
分类号 A61K31/444;A61K31/167;A61K31/216;A61P39/04;C07C67/343;C07C69/738;C07C205/56;C07C225/22;C07C229/44;C07C235/78;C07C237/20;C07D401/06;C12N9/99 主分类号 A61K31/444
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