| 摘要 |
Lipid vector delivering gene silencers which vector carries on its external surface at least one recognizing molecule directed against a cellular target molecule. The recognizing molecule is directed against GD2 disialoganglioside epitope, a tumor-associated membrane antigen expressed abundantly by neuroectodermal tumor cells, and which lipid vector contains as therapeutic agent double-stranded RNA synthetic oligonucleotides such as siRNAs (small interfering RNAs), complementary to mRNAs (messenger RNAs) coding for at least one oncogene such to obtain silencing, that is the selectively decreased expression of the oncogene, in target cells. |
