| 发明名称 |
Method for stabilizing an DNA insert in a recombinant vaccinia vector |
| 摘要 |
The present invention relates to a method of stabilizing an insert in a recombinant vaccinia virus by disrupting a run of 4 or more G or C residues through a substitution that introduces a silent mutation in the run, the length of which is thereby reduced. |
| 申请公布号 |
EP2402451(A3) |
申请公布日期 |
2012.04.18 |
| 申请号 |
EP20110183527 |
申请日期 |
2007.08.24 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MOSS, BERNARD;WYATT, LINDA;EARL, PATRICIA |
| 分类号 |
C12N15/863;A61K39/21;A61K48/00;C12N7/00;C12N15/85 |
主分类号 |
C12N15/863 |
| 代理机构 |
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代理人 |
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