| 摘要 |
PURPOSE: An N1-(phenethyl)-N2-substituted biguanide derivative is provided to ensure excellent blood glucose drop action and lipid lowering action even with a little dosage compared existing drug and to enable use for the treatment of diabetes, obesity, hyperlipidemia, hypercholesterolemia, steatosis, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer etc. CONSTITUTION: A compound or pharmaceutically acceptable salts are represented by chemical formula 1. In chemical formula 1, R is C1-12 alkyl, C1-12 alkenyl or C1-12 alkynyl substituted or unsubstituted with one or more substituents selected from C3-8 cycloalkyl and C5-12 aryl; C3-8 cycloalkyl substituted or unsubstituted with one or more substituents selected from halogen, hydroxyl, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C1-6 alkoxy and C5-12 aryl; and C5-12 aryl substituted or unsubstituted with one or more substituents selected from halogen, hydroxyl, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C1-6 alkoxy and C3-8 cycloalkyl.
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