| 摘要 |
A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided. A compound represented by the general formula (I): (see formula I) wherein R X is a group represented by the formula: (see formula IIa), (see formula IIb), (see formula IIc) or (see formula IId) wherein R1 is a hydrogen atoin, optionally substituted alkyl, etc.; Z is -O-, -N(R10)-, etc.; R10 is a hydrogen atom, alkyl, etc.; R2 is a hydrogen atom, optionally substituted alkyl, etc.; R18 is a hydrogen atom, optionally substituted alkyl, etc.; R19 is optionally substituted alkyl, etc.; W1 is an optionally substituted non-aromatic nitrogen-containing group; R17 is a hydrogen atom, optionally substituted alkyl, etc.; R3 and R4 are independently a hvdrogen atom, optionally substituted alkyl, etc.; X is -O-, -S-, or -N(R12)-, etc.; R12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.
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