IL-23 FOR TREATING CUTANEOUS WOUNDS

摘要

It is provided methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. It is further provided the use of an IL-23 complex for treating a cutaneous wound, the IL-2-3 complex comprising a polypeptide comprising residues 352 to 521 of SEQ ID NO: 8 or a conservatively modified variant thereof comprising an individual amino acid substitution; and a polypeptide comprising residues 25 to 330 of SEQ ID NO: 8 or a conservatively modified variant thereof comprising an individual amino acid substitution. It is also provided the use of an IL-23 fusion protein for treating a cutaneous wound, the IL-23 fusion protein comprising residues 352 to 521 of SEQ ID NO: 8 and residues 25 to 330 of SEQ ID NO: 8.