发明名称 |
PHARMACEUTICAL COMPOSITION FOR IMPROVING CEREBRAL FUNCTION AND METHOD FOR IMPROVING CEREBRAL FUNCTION |
摘要 |
An alkyl ether derivative represented by the formula: (see formula 1) wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.
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申请公布号 |
CA2488120(C) |
申请公布日期 |
2012.04.17 |
申请号 |
CA20032488120 |
申请日期 |
2003.04.03 |
申请人 |
TOYAMA CHEMICAL CO., LTD. |
发明人 |
NAKADA, YASUSHI;NAKAGAWA, MASAYA;ONO, SATOSHI |
分类号 |
A61K31/397;A61K31/122;A61K31/167;A61K31/21;A61K31/27;A61K31/381;A61K31/407;A61K31/445;A61K31/4706;A61K31/4709;A61K31/473;A61K31/4748;A61K31/496;A61K31/55;A61K45/06;A61P25/28;A61P43/00 |
主分类号 |
A61K31/397 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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