发明名称 |
Combined use of cell permeable Nanog and Oct4 for increasing self-renewal and suppressing differentiation of stem cells |
摘要 |
The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating the cells in combination with the cell permeable Nanog and Oct4 recombinant proteins, and the combined use of the cell permeable Nanog and Oct4 recombinant proteins for increasing self-renewal and suppressing differentiation of stem cells. |
申请公布号 |
US8158415(B2) |
申请公布日期 |
2012.04.17 |
申请号 |
US20080528919 |
申请日期 |
2008.02.27 |
申请人 |
JO DAE WOONG;KIM JIN SOOK;PARK YUN KYUNG;PROCELL THERAPEUTICS INC. |
发明人 |
JO DAE WOONG;KIM JIN SOOK;PARK YUN KYUNG |
分类号 |
C12N15/00;C07H21/02;C07K14/00 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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