发明名称 PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECABOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD
摘要 Disclosed is a process for producing A-form crystals of 2-(3-cyamo-4-isobutytoxyphenyl)-4-methyl-5-thiazotecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propmol, 2-propanol, ethanol, and acetone, a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent.
申请公布号 KR20120036363(A) 申请公布日期 2012.04.17
申请号 KR20127003728 申请日期 2010.07.14
申请人 TEIJIN PHARMA LIMITED 发明人 UEMURA AKIHITO;NOGATA TOMOAKI;TAKEYASU TAKUMI
分类号 C07D277/56;A61K31/426;A61P19/06;C07D277/20 主分类号 C07D277/56
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