发明名称 |
Threo-DOPS controlled release formulation |
摘要 |
The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations. |
申请公布号 |
US8158149(B2) |
申请公布日期 |
2012.04.17 |
申请号 |
US20070698974 |
申请日期 |
2007.01.29 |
申请人 |
PEROUTKA STEPHEN;SWARBRICK JAMES;CHELSEA THERAPEUTICS, INC. |
发明人 |
PEROUTKA STEPHEN;SWARBRICK JAMES |
分类号 |
A61K9/22;A01N37/44;A61K31/195 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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