摘要 |
PURPOSE: A pharmaceutical composition containing sodium lobarate is provided to suppress tyrosine phosphatase 1B and to treat type II diabetes. CONSTITUTION: A pharmaceutical composition for preventing or treating diabetes or obesity contains sodium lobarate of chemical formula 1 as an active ingredient. A functional food for preventing or treating diabetes or obesity contains sodium lovarate of chemical formula 1. Sodium lovarate is isolated from Stereocaulon alpinum extract. A method for preparing lovaric acid comprises: a step of extracting dried Stereocaulon alpinum using methanol for 24 hours; a step of distilling the solvent; a step of loading flash column chromatography filled with silicagel(C18); and a step of injecting 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%(v/v) methanol in order to obtain each fraction. |
申请人 |
KOREA OCEAN RESEARCH AND DEVELOPMENT INSTITUTE |
发明人 |
YIM, JOUNG HAN;KIM, IL CHAN;KIM, DOC KYU;HAN, SE JONG;LEE, HYOUNG SEOK;OH, HYUN CHEOL;JO, DONG GYU;PARK, MI RA;PARK, YU KYUNG;KIM, SUNG JIN;KIM, TAI KYOUNG;KANG, PIL SUNG;PARK, HEE YONG;PARK, HA JU |