发明名称 |
Pharmaceutical composition comprising metadoxine and garlic oil for preventing and treating alcohol-induced fatty liver and steatohepatitis |
摘要 |
Provided is a pharmaceutical or food or drink composition for preventing or treating alcohol-induced fatty liver or steatohepatitis comprising metadoxine (pyridoxol 1-2-pyrrolidone-5-carboxylate) and garlic oil as active ingredients. The concurrent administration of metadoxine and garlic oil according to the present invention exhibits outstandingly superior effects of inhibiting the accumulation of triglyceride and increase of blood AST (aspartate aminotransferase) level in liver el tissue, inhibiting the expression of FAS (fatty acid synthase), CYP2E1 and iNOS (inducible nitric oxide synthase) and inhibiting the deactivation of AMPK (AMP-activated protein kinase), as compared to the administration of metadoxine or garlic oil only. |
申请公布号 |
US8158170(B2) |
申请公布日期 |
2012.04.17 |
申请号 |
US20070516968 |
申请日期 |
2007.11.30 |
申请人 |
KIM SANG GEON;KI SUNG HWAN;CHOI JAE HOON;SNU R&DB FOUNDATION |
发明人 |
KIM SANG GEON;KI SUNG HWAN;CHOI JAE HOON |
分类号 |
A61K36/8962 |
主分类号 |
A61K36/8962 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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