发明名称 |
METHODS AND COMPOSITIONS FOR CONTROLLED POLYPEPTIDE SYNTHESIS |
摘要 |
Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed. |
申请公布号 |
US2012088848(A1) |
申请公布日期 |
2012.04.12 |
申请号 |
US201113076953 |
申请日期 |
2011.03.31 |
申请人 |
DEMING TIMOTHY J.;YU MIAOER;CURTIN SCOTT A.;HWANG JUNGYEON;WYRSTA MICHAEL D.;NOWAK ANDREW;SEIDEL SCOTT W. |
发明人 |
DEMING TIMOTHY J.;YU MIAOER;CURTIN SCOTT A.;HWANG JUNGYEON;WYRSTA MICHAEL D.;NOWAK ANDREW;SEIDEL SCOTT W. |
分类号 |
A61K47/34;B29C67/24;C07F15/00;C07F15/04;C07H21/00;C07K2/00;C08B37/00;C08G69/48;C08J3/205 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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