发明名称 |
TREATMENT METHODS USING DKK-1 ANTIBODIES |
摘要 |
The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed. |
申请公布号 |
US2012087912(A1) |
申请公布日期 |
2012.04.12 |
申请号 |
US201113323566 |
申请日期 |
2011.12.12 |
申请人 |
LI JI;SHEN WENYAN;LU HSIENG SEN;RICHARDS WILLIAM GLEASON;AMGEN INC. |
发明人 |
LI JI;SHEN WENYAN;LU HSIENG SEN;RICHARDS WILLIAM GLEASON |
分类号 |
A61K39/395;A61P1/00;A61P3/10;A61P11/00;A61P13/12;A61P17/00;A61P19/02;A61P21/00;A61P25/00;A61P25/16;A61P25/28;A61P27/02;A61P29/00;C07H21/04;C07K16/18;C12N5/10;C12N15/63;C12P21/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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