摘要 |
The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MARKS, JAMES D.;FAN, YONGFENG;LOU, JIANLONG;RODRIGUEZ, MARIA CONSUELO GARCIA;YAN, SHUDE;GEREN, ISIN NERGIZ;ZHAI, WENWU;CHAKRABORTI, SUBHENDU |
发明人 |
MARKS, JAMES D.;FAN, YONGFENG;LOU, JIANLONG;RODRIGUEZ, MARIA CONSUELO GARCIA;YAN, SHUDE;GEREN, ISIN NERGIZ;ZHAI, WENWU;CHAKRABORTI, SUBHENDU |