METHOD AND COMPOSITION FOR COMBINATORIAL-BASED PRODUCTION OF MULTIVALENT RECOMBINANT ANTIGEN

摘要

PROBLEM TO BE SOLVED: To provide methods and compositions that provide a population of antigen encoding nucleotide sequences in heterokaryotic filamentous fungi that can be used to produce a population of multivalent vaccines.

SOLUTION: The present invention provides the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.

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