发明名称 |
ENHANCED MSC PREPARATIONS |
摘要 |
The present invention provides preparations of MSCs with important therapeutic potential. The MSC cells are non-primary cells with an antigen profile comprising less than about 1.25% CD45+ cells (or less than about 0.75% CD45+), at least about 95% CD105+ cells, and at least about 95% CD166+ cells. Optionally, MSCs of the present preparations are isogenic and can be expanded ex vivo and cryopreserved and thawed, yet maintain a stable and uniform phenotype. Methods are taught here of expanding these MSCs to produce a clinical scale therapeutic preparations and medical uses thereof. |
申请公布号 |
US2012087933(A1) |
申请公布日期 |
2012.04.12 |
申请号 |
US201113267363 |
申请日期 |
2011.10.06 |
申请人 |
TOM SAMSON;TON CHRISTOPHER;DANILKOVITCH ALLA |
发明人 |
TOM SAMSON;TON CHRISTOPHER;DANILKOVITCH ALLA |
分类号 |
A61K35/28;A61P1/00;A61P5/14;A61P19/02;A61P29/00;A61P37/06;C12N5/0775 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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