| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides. <P>SOLUTION: The immunomodulatory polynucleotide is composed of more than 10 bases, and comprises: (a) a palindromic sequence comprising at least two CG dinucleotides, wherein the CG dinucleotides are separated by 0, 1, 2, 3, 4 or 5 bases and the palindromic sequence has a base composition of more than one-third As and Ts, and at least 8 bases in length; and (b) a (TCG)<SB POS="POST">y</SB>, (wherein y is 1 or 2, wherein the 5' T of the (TCG)<SB POS="POST">y</SB>is positioned 0, 1, 2 or 3 bases from the 5' end of the polynucleotide) and wherein the (TCG)<SB POS="POST">y'</SB>is separated from the 5' end of the palindromic sequence by 0, 1, or 2 bases. <P>COPYRIGHT: (C)2012,JPO&INPIT |
