发明名称 |
miRNAS AS THERAPEUTIC TARGETS IN CANCER |
摘要 |
Methods for modulating expression of a component of a cell, comprising contacting the cell with a nucleic acid comprising an miR-140 nucleic acid sequence in an amount sufficient to modulate the cellular component are provided. Overexpression of miR-140 inhibits cell proliferation in both U-2 OS (wt-p53) and HCT 116 (wt-p53) cell lines. Cells transfected with miR-140 are more resistant to chemotherapeutic agent methotrexate, mi-140 expression is related to HDAC4 protein expression. The claimed methods reduce the protein expression level of HDAC4 without degrading the target mRNA.
|
申请公布号 |
US2012087992(A1) |
申请公布日期 |
2012.04.12 |
申请号 |
US201013257836 |
申请日期 |
2010.03.22 |
申请人 |
JU JINGFANG;WANG YUAN;SONG BO |
发明人 |
JU JINGFANG;WANG YUAN;SONG BO |
分类号 |
A61K31/7088;A61K31/704;A61K33/24;A61N5/00;C07H21/02;C12N5/00;C12Q1/68 |
主分类号 |
A61K31/7088 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|