REGULATORS OF NFAT AND/OR STORE-OPERATED CALCIUM ENTRY
摘要
Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of septin 4 (SEPT 4) and septin 5 (SEPT 5) proteins involved in the calcineurin/NFAT axis and T-cell activation.
申请公布号
WO2012048316(A2)
申请公布日期
2012.04.12
申请号
WO2011US55561
申请日期
2011.10.10
申请人
IMMUNE DISEASE INSTITUTE, INC.;RAO, ANJANA;HOGAN, PATRICK;SHARMA, SONIA