发明名称 |
METHOD FOR DETERMINING CANCER PATIENT SURVIVAL BASED ON ANALYZING TUMOR-INFILTRATING OVERALL T-LYMPHOCYTES |
摘要 |
The present invention relates to a method, in vitro or in vivo, for determining cancer patient survival, comprising analyzing the number and/or amount of tumor-infiltrating overall T- lymphocytes (oTLs) based on the methylation status of at least one CpG position in one or more of the genes for CD3 ?, -d, and -e in a tumor sample derived from said cancer patient, wherein a high number and/or amount of oTLs is indicative for a better survival of said cancer patient in a non-breast cancer, wherein in breast cancer a high number and/or amount of oTLs is indicative for an inferior survival of said patient. The present invention also relates to a respective kit for use in the methods of the invention. |
申请公布号 |
WO2012045888(A1) |
申请公布日期 |
2012.04.12 |
申请号 |
WO2011EP67660 |
申请日期 |
2011.10.10 |
申请人 |
EPIONTIS GMBH;OLEK, SVEN;SCHWACHULA, TIM;BARON, UDO |
发明人 |
OLEK, SVEN;SCHWACHULA, TIM;BARON, UDO |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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