发明名称 |
HDAC INHIBITORS TO TREAT CHARCOT-MARIE-TOOTH DISEASE |
摘要 |
The present application relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, most particularly, Charcot-Marie-Tooth (CMT) disease. It is shown that this disease is associated with decreased acetylated tubulin levels, which can be overcome by inhibition of histone deacetylases (HDACs). Using HDAC inhibitors, it is shown herein that the symptoms of the CMT phenotype can be overcome both in vitro and in vivo. Also provided herein are two different mouse models of CMT disease.
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申请公布号 |
CA2812855(A1) |
申请公布日期 |
2012.04.12 |
申请号 |
CA20112812855 |
申请日期 |
2011.10.06 |
申请人 |
VIB VZW;LIFE SCIENCES RESEARCH PARTNERS VZW |
发明人 |
VAN DEN BOSCH, LUDO;VAN OUTRYVE D'YDEWALLE, CONSTANTIN;ROBBERECHT, WIM |
分类号 |
A61K31/422;A01K67/027;A61K31/437;A61P25/28 |
主分类号 |
A61K31/422 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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