ORAL SOLID PREPARATION COMPOSITION CONTAINING SILYMARIN USING MEMBRANE EMULSIFICATION TECHNIQUE, AND ITS PRODUCTION METHOD

摘要

PURPOSE: An oral solid preparation composition of silymarin is provided to improve solubility, bioavailability, and medicine compliance. CONSTITUTION: An oral solid preparation composition of silymarin contains 30-70 wt% of silymarin as an active ingredient, 10-40 wt% of castor oil as an oil ingredient, 10-25 wt% of a mixture of tween 80 and transcutol P as surfactant, and 6-30 wt% of polyvinyl pyrrolidone K30(PVP K30). A method for manufacturing the composition comprises: a step of mixing the ingredients by a membrane emulsification technique; and a step of spray-drying the prepared emulsion.