发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE INTERACTIONS |
摘要 |
The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGFp). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts. |
申请公布号 |
WO2012048291(A2) |
申请公布日期 |
2012.04.12 |
申请号 |
WO2011US55471 |
申请日期 |
2011.10.07 |
申请人 |
PROTEAPEX THERAPEUTICS LLC;D'ANGELO, MARINA;SELIM, ABDULHAFEZ |
发明人 |
D'ANGELO, MARINA;SELIM, ABDULHAFEZ |
分类号 |
A61K38/48;A61K38/55;A61P19/00;A61P19/02;C07K14/81;C07K16/40;C12N9/64 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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