发明名称 |
MATERIALS AND METHODS FOR INCREASING HSP20 ACTIVITY |
摘要 |
The present invention provides methods and materials for use in increasing HSP20 activation in a biological system, for example by increasing phosphorylation of Ser16 of HSP20. In one aspect, the invention provides a method for increasing HSP20 activation in a biological system, comprising contacting the system with an antagonist capable of inhibiting PDE4 binding to HSP20, the antagonist comprising or consisting essentially of a fragment of PDE4 or an analogue thereof. In a further aspect the invention provides a method of screening for an agent able to increase activation of HSP20. A preferred antagonist has a C-termina! lysine residue. |
申请公布号 |
WO2012046008(A2) |
申请公布日期 |
2012.04.12 |
申请号 |
WO2011GB01457 |
申请日期 |
2011.10.07 |
申请人 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW;BAILLIE, GEORGE;HOUSLAY, MILES;DAY, JON |
发明人 |
BAILLIE, GEORGE;HOUSLAY, MILES;DAY, JON |
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