发明名称 |
THERAPEUTIC AND DIAGNOSTIC MOLECULES |
摘要 |
The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided. |
申请公布号 |
EP2438167(A1) |
申请公布日期 |
2012.04.11 |
申请号 |
EP20100782840 |
申请日期 |
2010.06.04 |
申请人 |
CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY;THE UNIVERSITY OF SYDNEY;MEDVET SCIENCE PTY. LTD.;WENKART FOUNDATION |
发明人 |
GAMBLE, JENNIFER;VADAS, MATHEW;GOODALL, GREGORY;YOUNG, JENNIFER |
分类号 |
C12N15/113;A61K48/00;A61P9/10;A61P35/00;C07H21/02 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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