发明名称 |
COMBINATIONS OF PNEUMOCOCCAL RrgB CLADES |
摘要 |
Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain. |
申请公布号 |
EP2437777(A1) |
申请公布日期 |
2012.04.11 |
申请号 |
EP20100723798 |
申请日期 |
2010.06.01 |
申请人 |
NOVARTIS AG |
发明人 |
MASIGNANI, VEGA;BAROCCHI, MICHELE ANNE;MOSCHIONI, MONICA;RUGGIERO, PAOLO |
分类号 |
A61K39/09 |
主分类号 |
A61K39/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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