发明名称 |
COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASES MEDIATED BY THE ACTIVATION OF AMPK AND INCLUDING 2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS ACTIVE INGREDIENTS |
摘要 |
The present invention relates to a 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan compound which activates nutmeg-derived AMP-activated protein kinase (AMPK), and to a composition including same as active ingredients for preventing and treating metabolic syndromes such as obesity. More particularly, the present invention relates to an AMPK-activating compound comprising one of the 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan-based compounds produced by extracting Myristica fragrans with a solution of 30% or less of ethanol and separating and purifying the extracts using chromatography, as expressed in chemical formula 1 below, and to a composition comprising same as an active ingredient for preventing and treating metabolic syndrome caused by AMPK enzyme activation, such as obesity, diabetes, high cholesterol and cardiopulmonary diseases. |
申请公布号 |
EP2438923(A1) |
申请公布日期 |
2012.04.11 |
申请号 |
EP20090845576 |
申请日期 |
2009.06.26 |
申请人 |
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY;AMOREPACIFIC CORPORATION |
发明人 |
OH, WON KEUN;NGUYEN, PHI HUNG;LE, THI VAN THU;KANG, HU WON;SHIN, EUI SEOK;CHIO, JIN KYU;SEO, DAE BANG;LEE, SANG JUN |
分类号 |
A61K36/185;A61K31/341;A61P3/04 |
主分类号 |
A61K36/185 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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